1v79: Difference between revisions

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Bots, Bureaucrats, journal, Administrators
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No edit summary
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[[Image:1v79.gif|left|200px]]
{{Seed}}
[[Image:1v79.png|left|200px]]


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{{STRUCTURE_1v79|  PDB=1v79  |  SCENE=  }}  
{{STRUCTURE_1v79|  PDB=1v79  |  SCENE=  }}  


'''Crystal structures of adenosine deaminase complexed with potent inhibitors'''
===Crystal structures of adenosine deaminase complexed with potent inhibitors===




==Overview==
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We disclose optimization efforts based on the novel non-nucleoside adenosine deaminase (ADA) inhibitor, 4 (K(i) = 680 nM). Structure-based drug design utilizing the crystal structure of the 4/ADA complex led to discovery of 5 (K(i) = 11 nM, BA = 30% in rats). Furthermore, from metabolic considerations, we discovered two inhibitors with improved oral bioavailability [6 (K(i) = 13 nM, BA = 44%) and 7 (K(i) = 9.8 nM, BA = 42%)]. 6 demonstrated in vivo efficacy in models of inflammation and lymphoma.
The line below this paragraph, {{ABSTRACT_PUBMED_15139750}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15139750 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15139750}}


==About this Structure==
==About this Structure==
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Zinc]]
[[Category: Zinc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:10:36 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:46:44 2008''
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