7i2e: Difference between revisions
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==Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z740611958 (DNV2_NS5A-x0264)== | |||
<StructureSection load='7i2e' size='340' side='right'caption='[[7i2e]], [[Resolution|resolution]] 1.72Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7i2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7I2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7I2E FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1BZQ:~{N}-[(1~{S})-1-(2,4-dimethyl-1,3-thiazol-5-yl)ethyl]-2-methyl-propanamide'>A1BZQ</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7i2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7i2e OCA], [https://pdbe.org/7i2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7i2e RCSB], [https://www.ebi.ac.uk/pdbsum/7i2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7i2e ProSAT]</span></td></tr> | ||
[[Category: Aschenbrenner | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/Q91H74_9FLAV Q91H74_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS026470_004_099774] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Dengue virus 2]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Arnold E]] | ||
[[Category: | [[Category: Aschenbrenner JC]] | ||
[[Category: Balcomb BH]] | |||
[[Category: Chopra A]] | |||
[[Category: Fearon D]] | |||
[[Category: Lithgo RM]] | |||
[[Category: Marples PG]] | |||
[[Category: Ruiz FX]] | |||
[[Category: Saini M]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 08:26, 2 April 2025
Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z740611958 (DNV2_NS5A-x0264)
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