1v9e: Difference between revisions

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[[Image:1v9e.~~gif~~|left|200px]]

[[Image:1v9e.png|left|200px]]

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~~'''~~Crystal Structure Analysis of Bovine Carbonic Anhydrase II~~'''~~

===Crystal Structure Analysis of Bovine Carbonic Anhydrase II===

~~==Overview==~~

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~~Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes~~ the ~~reversible hydration of CO2~~ to ~~HCO3-. In eukaryotes,~~ the enzyme plays a role in various physiological functions, including interconversion between CO2 and HCO3- in intermediary metabolism, facilitated diffusion of CO2, pH homeostasis and ion transport. The structure of bovine carbonic anhydrase II (~~BCA II) has been determined by molecular replacement and refined to 1~~.~~95 A resolution by simulated-annealing and individual B-factor refinement~~. ~~The final R factor for~~ the ~~BCA II structure was 19~~.~~4%. BCA II has a C~~-terminal knot structure similar to that observed in human CA II. It contains one zinc ion in the active site coordinated to three histidines and one putative water molecule in a tetrahedral geometry. The structure of BCA II reveals a probable alternative proton-~~wire pathway that differs from that of HCA II.~~

The line below this paragraph, {{ABSTRACT_PUBMED_15039588}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15039588 is the PubMed ID number.

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==About this Structure==

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[[Category: Twisted beta sheet]]

[[Category: Zinc metalloenzyme]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:15:37 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:23:18 2008''

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-[[Image:1v9e.gif|left|200px]]
+{{Seed}}
+[[Image:1v9e.png|left|200px]]
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 {{STRUCTURE_1v9e|  PDB=1v9e  |  SCENE=  }}
-'''Crystal Structure Analysis of Bovine Carbonic Anhydrase II'''
+===Crystal Structure Analysis of Bovine Carbonic Anhydrase II===
-==Overview==
+<!--
-Carbonic anhydrase (CA) is a zinc-containing enzyme that catalyzes the reversible hydration of CO2 to HCO3-. In eukaryotes, the enzyme plays a role in various physiological functions, including interconversion between CO2 and HCO3- in intermediary metabolism, facilitated diffusion of CO2, pH homeostasis and ion transport. The structure of bovine carbonic anhydrase II (BCA II) has been determined by molecular replacement and refined to 1.95 A resolution by simulated-annealing and individual B-factor refinement. The final R factor for the BCA II structure was 19.4%. BCA II has a C-terminal knot structure similar to that observed in human CA II. It contains one zinc ion in the active site coordinated to three histidines and one putative water molecule in a tetrahedral geometry. The structure of BCA II reveals a probable alternative proton-wire pathway that differs from that of HCA II.
+The line below this paragraph, {{ABSTRACT_PUBMED_15039588}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15039588 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15039588}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Twisted beta sheet]]
 [[Category: Zinc metalloenzyme]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:15:37 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 10:23:18 2008''