9lvg: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9lvg is ~~ON HOLD until Paper Publication~~

==Crystal structure of the mouse RIP3 kinase domain in complexed with Robinetin==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[9lvg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LVG OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9LVG FirstGlance].

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKR:3,7-bis(oxidanyl)-2-[3,4,5-tris(oxidanyl)phenyl]chromen-4-one'>LKR</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9lvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lvg OCA], [https://pdbe.org/9lvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lvg RCSB], [https://www.ebi.ac.uk/pdbsum/9lvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lvg ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Li MJ]]

[[Category: Su HX]]

[[Category: Xie H]]

[[Category: Xu YC]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9lvg is ON HOLD  until Paper Publication
+==Crystal structure of the mouse RIP3 kinase domain in complexed with Robinetin==
+<StructureSection load='9lvg' size='340' side='right'caption='[[9lvg]], [[Resolution|resolution]] 2.03&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9lvg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LVG FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.03&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LKR:3,7-bis(oxidanyl)-2-[3,4,5-tris(oxidanyl)phenyl]chromen-4-one'>LKR</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lvg OCA], [https://pdbe.org/9lvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lvg RCSB], [https://www.ebi.ac.uk/pdbsum/9lvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lvg ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/RIPK3_MOUSE RIPK3_MOUSE] Essential for programmed necrosis in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).<ref>PMID:19590578</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Li MJ]]
+[[Category: Su HX]]
+[[Category: Xie H]]
+[[Category: Xu YC]]