9qfu: Difference between revisions
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==Human Tryptase beta-2 (hTPSB2) complexed with covalent inhibitor Compound #1== | |||
<StructureSection load='9qfu' size='340' side='right'caption='[[9qfu]], [[Resolution|resolution]] 1.98Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qfu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QFU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QFU FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.983Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1I52:~{N}-[(1~{S},2~{S})-6-azanyl-1-[5-[[4-[2-(3,4-dichlorophenyl)ethoxy]phenyl]methyl]-1,2,4-oxadiazol-3-yl]-1-oxidanyl-hexan-2-yl]-4-fluoranyl-benzamide'>A1I52</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qfu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qfu OCA], [https://pdbe.org/9qfu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qfu RCSB], [https://www.ebi.ac.uk/pdbsum/9qfu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qfu ProSAT]</span></td></tr> | ||
[[Category: Beccari | </table> | ||
[[Category: Beeg | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/TRYB2_HUMAN TRYB2_HUMAN] Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity). | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Summa | [[Category: Beccari AR]] | ||
[[Category: Beeg M]] | |||
[[Category: Brindisi M]] | |||
[[Category: Gobbi M]] | |||
[[Category: Iaconis D]] | |||
[[Category: Manelfi C]] | |||
[[Category: Porta A]] | |||
[[Category: Summa V]] | |||
[[Category: Talarico C]] | |||
Latest revision as of 21:55, 26 March 2025
Human Tryptase beta-2 (hTPSB2) complexed with covalent inhibitor Compound #1
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