1vaf: Difference between revisions

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[[Image:1vaf.gif|left|200px]]
{{Seed}}
[[Image:1vaf.png|left|200px]]


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{{STRUCTURE_1vaf|  PDB=1vaf  |  SCENE=  }}  
{{STRUCTURE_1vaf|  PDB=1vaf  |  SCENE=  }}  


'''Inducible nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477'''
===Inducible nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477===




==Overview==
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The high level of amino acid conservation and structural similarity of the substrate-binding sites of the oxygenase domains of the nitric oxide synthase (NOS) isoforms (eNOSoxy, iNOSoxy, nNOSoxy) make the interpretation of the structural basis of inhibitor isoform specificity a challenge, and provide few clues for the design of new selective compounds. Crystal structures of iNOSoxy and nNOSoxy complexed with the neuronal NOS-specific inhibitor AR-R17447 suggest that specificity is provided by the interaction of the chlorophenyl group with an isoform-unique substrate access channel residue (L337 in rat neuronal NOS, N115 in mouse inducible NOS). This is confirmed by biochemical analysis of site-directed mutants. Inhibitors combining guanidinium-like structural motifs with long chains specifically targeting this residue are good candidates for rational isoform-specific drug design. Based on this finding, modifications of AR-R17447 to improve the specificity for the human isoforms are suggested.
The line below this paragraph, {{ABSTRACT_PUBMED_15071192}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15071192 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15071192}}


==About this Structure==
==About this Structure==
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[[Category: Vasan, R.]]
[[Category: Vasan, R.]]
[[Category: Murine inosoxy inhibitor complex]]
[[Category: Murine inosoxy inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:17:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:15:02 2008''

Revision as of 17:15, 28 July 2008

File:1vaf.png

Template:STRUCTURE 1vaf

Inducible nitric oxide synthase oxygenase domain complexed with the inhibitor AR-R17477

Template:ABSTRACT PUBMED 15071192

About this Structure

1VAF is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design., Fedorov R, Vasan R, Ghosh DK, Schlichting I, Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5892-7. Epub 2004 Apr 7. PMID:15071192

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