9j76: Difference between revisions
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==Cryo-EM structure of URAT1 in complex with sulfinpyrazone== | |||
<StructureSection load='9j76' size='340' side='right'caption='[[9j76]], [[Resolution|resolution]] 3.51Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9j76]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9J76 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9J76 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.51Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EAY:1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione'>A1EAY</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9j76 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9j76 OCA], [https://pdbe.org/9j76 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9j76 RCSB], [https://www.ebi.ac.uk/pdbsum/9j76 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9j76 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/S22AC_RAT S22AC_RAT] Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:21074513). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:21074513). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:21074513). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (By similarity). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption. Orotate transport is Cl(-)-dependent (By similarity).[UniProtKB:Q96S37]<ref>PMID:21074513</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Yu Z]] | |||
[[Category: Zhao Y]] | |||
Latest revision as of 08:19, 13 August 2025
Cryo-EM structure of URAT1 in complex with sulfinpyrazone
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