1vdc: Difference between revisions

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[[Image:1vdc.gif|left|200px]]
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{{STRUCTURE_1vdc|  PDB=1vdc  |  SCENE=  }}  
{{STRUCTURE_1vdc|  PDB=1vdc  |  SCENE=  }}  


'''STRUCTURE OF NADPH DEPENDENT THIOREDOXIN REDUCTASE'''
===STRUCTURE OF NADPH DEPENDENT THIOREDOXIN REDUCTASE===




==Overview==
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Thioredoxin exists in all organisms and is responsible for the hydrogen transfer to important enzymes for ribonucleotide reduction and the reduction of methionine sulphoxide and sulphate. Thioredoxins have also been shown to regulate enzyme activity in plants and are also involved in the regulation of transcription factors and several other regulatory activities. Thioredoxin is reduced by the flavoenzyme thioredoxin reductase using NADPH. We have now determined the first structure of a eukaryotic thioredoxin reductase, from the plant Arabidopsis thaliana, at 2.5 A resolution. The dimeric A. thaliana thioredoxin reductase is structurally similar to that of the Escherichia coli enzyme, and most differences occur in the loops. Because the plant and E. coli enzymes have the same architecture, with the same dimeric structure and the same position of the redox active disulphide bond, a similar mechanism that involves very large domain rotations is likely for the two enzymes. The subunit is divided into two domains, one that binds FAD and one that binds NADPH. The relative positions of the domains in A. thaliana thioredoxin reductase differ from those of the E. coli reductase. When the FAD domains are superimposed, the NADPH domain of A. thaliana thioredoxin reductase must be rotated by 8 degrees to superimpose on the corresponding domain of the E. coli enzyme. The domain rotation we now observe is much smaller than necessary for the thioredoxin reduction cycle.
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==About this Structure==
==About this Structure==
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[[Category: Redox-active center]]
[[Category: Redox-active center]]
[[Category: Thioredoxin reductase]]
[[Category: Thioredoxin reductase]]
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Revision as of 07:22, 28 July 2008

File:1vdc.png

Template:STRUCTURE 1vdc

STRUCTURE OF NADPH DEPENDENT THIOREDOXIN REDUCTASE

Template:ABSTRACT PUBMED 9000629

About this Structure

1VDC is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Crystal structure of Arabidopsis thaliana NADPH dependent thioredoxin reductase at 2.5 A resolution., Dai S, Saarinen M, Ramaswamy S, Meyer Y, Jacquot JP, Eklund H, J Mol Biol. 1996 Dec 20;264(5):1044-57. PMID:9000629

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