9m4p: Difference between revisions
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==Cryo-EM structure of alpha-hemolysin heptameric pore state in the presence of RBC== | |||
<StructureSection load='9m4p' size='340' side='right'caption='[[9m4p]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9m4p]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9M4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9M4P FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9m4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9m4p OCA], [https://pdbe.org/9m4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9m4p RCSB], [https://www.ebi.ac.uk/pdbsum/9m4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9m4p ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Chatterjee | == Function == | ||
[[Category: Dutta | [https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Chatterjee A]] | |||
[[Category: Dutta S]] | |||
[[Category: Roy A]] | |||
Latest revision as of 06:27, 26 November 2025
Cryo-EM structure of alpha-hemolysin heptameric pore state in the presence of RBC
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