1vg0: Difference between revisions

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[[Image:1vg0.~~jpg~~|left|200px]]

[[Image:1vg0.png|left|200px]]

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~~'''~~The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein~~'''~~

===The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein===

~~==Overview==~~

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~~Members of the RabGDI/REP family serve as multifunctional regulators of the Rab family of GTP binding proteins. Mutations in members of~~ this ~~family~~, ~~such as REP-1~~, ~~lead~~ to ~~abnormalities, including progressive retinal degradation~~ (choroideremia) in humans. The crystal structures of the REP-1 protein in complex with monoprenylated or C-terminally truncated Rab7 proteins revealed that Rab7 interacts with the Rab binding platform of REP-1 via an extended interface involving the Switch 1 and 2 regions. The C terminus of the REP-1 molecule functions as ~~a mobile lid covering a conserved hydrophobic patch~~ on ~~the surface of REP-1 that in the complex coordinates the C terminus of Rab proteins~~. ~~Using semisynthetic fluorescent Rab27A, we demonstrate that although Rab27A can be prenylated by REP-2, this reaction can be effectively inhibited by other Rab proteins~~, ~~providing a possible explanation for~~ the ~~accumulation of unprenylated Rab27A in choroideremia~~.

The line below this paragraph, {{ABSTRACT_PUBMED_15186776}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 15186776 is the PubMed ID number.

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==About this Structure==

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[[Category: Post-translational modification]]

[[Category: Rab prenylation]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:29:56 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:54:26 2008''

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-[[Image:1vg0.jpg|left|200px]]
+{{Seed}}
+[[Image:1vg0.png|left|200px]]
 <!--
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 {{STRUCTURE_1vg0|  PDB=1vg0  |  SCENE=  }}
-'''The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein'''
+===The crystal structures of the REP-1 protein in complex with monoprenylated Rab7 protein===
-==Overview==
+<!--
-Members of the RabGDI/REP family serve as multifunctional regulators of the Rab family of GTP binding proteins. Mutations in members of this family, such as REP-1, lead to abnormalities, including progressive retinal degradation (choroideremia) in humans. The crystal structures of the REP-1 protein in complex with monoprenylated or C-terminally truncated Rab7 proteins revealed that Rab7 interacts with the Rab binding platform of REP-1 via an extended interface involving the Switch 1 and 2 regions. The C terminus of the REP-1 molecule functions as a mobile lid covering a conserved hydrophobic patch on the surface of REP-1 that in the complex coordinates the C terminus of Rab proteins. Using semisynthetic fluorescent Rab27A, we demonstrate that although Rab27A can be prenylated by REP-2, this reaction can be effectively inhibited by other Rab proteins, providing a possible explanation for the accumulation of unprenylated Rab27A in choroideremia.
+The line below this paragraph, {{ABSTRACT_PUBMED_15186776}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 15186776 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_15186776}}
 ==About this Structure==
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 [[Category: Post-translational modification]]
 [[Category: Rab prenylation]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:29:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:54:26 2008''