1vg8: Difference between revisions

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[[Image:1vg8.jpg|left|200px]]
{{Seed}}
[[Image:1vg8.png|left|200px]]


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{{STRUCTURE_1vg8|  PDB=1vg8  |  SCENE=  }}  
{{STRUCTURE_1vg8|  PDB=1vg8  |  SCENE=  }}  


'''GPPNHP-Bound Rab7'''
===GPPNHP-Bound Rab7===




==Overview==
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Members of the RabGDI/REP family serve as multifunctional regulators of the Rab family of GTP binding proteins. Mutations in members of this family, such as REP-1, lead to abnormalities, including progressive retinal degradation (choroideremia) in humans. The crystal structures of the REP-1 protein in complex with monoprenylated or C-terminally truncated Rab7 proteins revealed that Rab7 interacts with the Rab binding platform of REP-1 via an extended interface involving the Switch 1 and 2 regions. The C terminus of the REP-1 molecule functions as a mobile lid covering a conserved hydrophobic patch on the surface of REP-1 that in the complex coordinates the C terminus of Rab proteins. Using semisynthetic fluorescent Rab27A, we demonstrate that although Rab27A can be prenylated by REP-2, this reaction can be effectively inhibited by other Rab proteins, providing a possible explanation for the accumulation of unprenylated Rab27A in choroideremia.
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(as it appears on PubMed at http://www.pubmed.gov), where 15186776 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15186776}}


==About this Structure==
==About this Structure==
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[[Category: Rak, A.]]
[[Category: Rak, A.]]
[[Category: Gtp-binding protein]]
[[Category: Gtp-binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:30:23 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 02:47:25 2008''

Revision as of 23:47, 28 July 2008

File:1vg8.png

Template:STRUCTURE 1vg8

GPPNHP-Bound Rab7

Template:ABSTRACT PUBMED 15186776

About this Structure

1VG8 is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease., Rak A, Pylypenko O, Niculae A, Pyatkov K, Goody RS, Alexandrov K, Cell. 2004 Jun 11;117(6):749-60. PMID:15186776

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