Sandbox Reserved 1850: Difference between revisions
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<Structure load='4o5t' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | <Structure load='4o5t' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' /> | ||
The DA_20_10 model of the Diels Alderase was further enhanced by players of the online game "Foldit." Building on preliminary early data, players were asked to optimize various helical structures that would surround and support the ligand. After over 100,000 designs were tested, the top-scoring CE6 model was finalized, containing as <scene name='10/1075252/Alpha_helix_highlighted/4'>alpha helix cap</scene> that favorably constrains ligand orientation. This "cap" consists of two helices--helix one spans from residues 36-44, and helix two spans from residues 48-56. [cite Eiben] | The DA_20_10 model of the Diels Alderase was further enhanced by players of the online game "Foldit." Building on preliminary early data, players were asked to optimize various helical structures that would surround and support the ligand. After over 100,000 designs were tested, the top-scoring CE6 model was finalized, containing as <scene name='10/1075252/Alpha_helix_highlighted/4'>alpha helix cap</scene> that favorably constrains ligand orientation. This "cap" consists of two helices--helix one spans from residues 36-44, and helix two spans from residues 48-56. [cite Eiben] | ||
==Kinetics== | |||
==Applications== | ==Applications== | ||
