9qed: Difference between revisions
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==Cryo-EM structure of the XPF-ERCC1-SLX4(330-555)-SLX4IP complex== | |||
<StructureSection load='9qed' size='340' side='right'caption='[[9qed]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9qed]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QED OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QED FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qed FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qed OCA], [https://pdbe.org/9qed PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qed RCSB], [https://www.ebi.ac.uk/pdbsum/9qed PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qed ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SLX4I_HUMAN SLX4I_HUMAN] Chromosomal aberrations involving SLX4IP are found in acute lymphoblastic leukemia. A site-specific deletion within the 5' region of SLX4IP is found in 30% of childhood acute lymphoblastic leukemia in general and more than 60% of ETV6/RUNX1-rearranged acute lymphoblastic leukemia. Breakpoints within SLX4IP reveal junctions with typical characteristics of illegitimate V(D)J mediated recombination. SLX4IP deletions are significantly associated with male gender and ETV6/RUNX1-rearranged acute lymphoblastic leukemia.<ref>PMID:24045615</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SLX4I_HUMAN SLX4I_HUMAN] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cronin NB]] | |||
[[Category: Feng J]] | |||
[[Category: Greber BJ]] | |||
Latest revision as of 13:09, 17 December 2025
Cryo-EM structure of the XPF-ERCC1-SLX4(330-555)-SLX4IP complex
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