Sandbox Reserved 1849: Difference between revisions

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==Introduction==

===What are Minibinders?===

These mini proteins target the interaction between ACE2 and COVID-19 spike protein <ref name="Longxing">PMID:32907861</ref>. The minibinders are small proteins carefully designed to bind to the COVID-19 spike protein with a greater affinity than ACE2 <ref name="Longxing">PMID:32907861</ref>. These minibinders were able to reduce the viral burden of SARS-CoV-2 in mice <ref name="Case">PMID:34192518</ref>. These proteins were de novo (from scratch) designs to mimic the ACE2 helix, but have a lower dissociation constant, yielding a greater affinity for the spike protein <ref name="Longxing">PMID:32907861</ref>. The binding region between <scene name='10/1075251/Ace2_and_rbd/3~~' caption='This works?~~'>spike protein and ACE2</scene> can give a better explanation as to how these proteins were designed.

These mini proteins target the interaction between ACE2 and COVID-19 spike protein <ref name="Longxing">PMID:32907861</ref>. The minibinders are small proteins carefully designed to bind to the COVID-19 spike protein with a greater affinity than ACE2 <ref name="Longxing">PMID:32907861</ref>. These minibinders were able to reduce the viral burden of SARS-CoV-2 in mice <ref name="Case">PMID:34192518</ref>. These proteins were de novo (from scratch) designs to mimic the ACE2 helix, but have a lower dissociation constant, yielding a greater affinity for the spike protein <ref name="Longxing">PMID:32907861</ref>. The binding region between <scene name='10/1075251/Ace2_and_rbd/3'>spike protein and ACE2</scene> (PDB: [https://www.rcsb.org/structure/8K4U 8K4U] can give a better explanation as to how these proteins were designed.

[[Image:Untitled presentation.jpg|500 px|right|thumb|Figure 1. Image of the individual helices of AHB2, LCB1, and LCB3, respectively.]]

Sandbox Reserved 1849: Difference between revisions

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@@ Line 5: / Line 5: @@
 ==Introduction==
 ===What are Minibinders?===
-These mini proteins target the interaction between ACE2 and COVID-19 spike protein <ref name="Longxing">PMID:32907861</ref>. The minibinders are small proteins carefully designed to bind to the COVID-19 spike protein with a greater affinity than ACE2 <ref name="Longxing">PMID:32907861</ref>. These minibinders were able to reduce the viral burden of SARS-CoV-2 in mice <ref name="Case">PMID:34192518</ref>. These proteins were de novo (from scratch) designs to mimic the ACE2 helix, but have a lower dissociation constant, yielding a greater affinity for the spike protein <ref name="Longxing">PMID:32907861</ref>. The binding region between <scene name='10/1075251/Ace2_and_rbd/3' caption='This works?'>spike protein and ACE2</scene> can give a better explanation as to how these proteins were designed.
+These mini proteins target the interaction between ACE2 and COVID-19 spike protein <ref name="Longxing">PMID:32907861</ref>. The minibinders are small proteins carefully designed to bind to the COVID-19 spike protein with a greater affinity than ACE2 <ref name="Longxing">PMID:32907861</ref>. These minibinders were able to reduce the viral burden of SARS-CoV-2 in mice <ref name="Case">PMID:34192518</ref>. These proteins were de novo (from scratch) designs to mimic the ACE2 helix, but have a lower dissociation constant, yielding a greater affinity for the spike protein <ref name="Longxing">PMID:32907861</ref>. The binding region between <scene name='10/1075251/Ace2_and_rbd/3'>spike protein and ACE2</scene> (PDB: [https://www.rcsb.org/structure/8K4U 8K4U] can give a better explanation as to how these proteins were designed.
 [[Image:Untitled presentation.jpg|500 px|right|thumb|Figure 1. Image of the individual helices of AHB2, LCB1, and LCB3, respectively.]]