Engineered Protein Inhibitors of SARS-CoV-2 Entry: Difference between revisions
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==Conclusion== | ==Conclusion== | ||
The inhibitors LCB1 and LCB3 were shown to be the most effective at inhibiting the virus by having the highest affinity for the RBD and as well as the highest neutralization effect as seen in figure 5 <ref name="Cao">DOI:10.1126/science.abd9909</ref>. While AHB2 wasn't as effective as LCB1 and LCB3 at neutralizing the virus, it still showed results of being an effective vaccine as it still had a higher binding affinity to the RBD compared to ACE2. | The inhibitors LCB1 and LCB3 were shown to be the most effective at inhibiting the virus by having the highest affinity for the RBD and as well as the highest neutralization effect as seen in figure 5 <ref name="Cao">DOI:10.1126/science.abd9909</ref>. While AHB2 wasn't as effective as LCB1 and LCB3 at neutralizing the virus, it still showed results of being an effective vaccine as it still had a higher binding affinity to the RBD compared to ACE2.All three inhibitors show more advantages as a vaccine compared to antibodies due to their small size, stability and their ability to be quickly modified <ref name="Cao">DOI:10.1126/science.abd9909</ref>. | ||
[[Image:KdValues.jpg|400 px|right|thumb|Figure 5: The binding affinity values (Kd) and the half maximum inhibitory concentration values (IC50) are shown for ACE2, AHB2, LCB1 and LCB3<ref name="Cao">DOI:10.1126/science.abd9909</ref>.]] | [[Image:KdValues.jpg|400 px|right|thumb|Figure 5: The binding affinity values (Kd) and the half maximum inhibitory concentration values (IC50) are shown for ACE2, AHB2, LCB1 and LCB3<ref name="Cao">DOI:10.1126/science.abd9909</ref>.]] | ||
</StructureSection> | </StructureSection> | ||
