9o4y: Difference between revisions
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==GAS41 YEATS domain in complex with DLG-1== | |||
<StructureSection load='9o4y' size='340' side='right'caption='[[9o4y]], [[Resolution|resolution]] 2.30Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9o4y]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O4Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O4Y FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1B9P:(2~{S})-~{N}-[5-[3-[5-[3-(aminomethyl)phenyl]-1,3-thiazol-2-yl]azetidin-1-yl]carbonylthiophen-2-yl]pyrrolidine-2-carboxamide'>A1B9P</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o4y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o4y OCA], [https://pdbe.org/9o4y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o4y RCSB], [https://www.ebi.ac.uk/pdbsum/9o4y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o4y ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/YETS4_HUMAN YETS4_HUMAN] Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.<ref>PMID:14966270</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cierpicki T]] | |||
[[Category: Clegg BD]] | |||
[[Category: Grembecka J]] | |||
[[Category: Linhares BM]] | |||
[[Category: Winkler A]] | |||
Revision as of 07:36, 25 February 2026
GAS41 YEATS domain in complex with DLG-1
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