9ugj: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9ugj is ~~ON HOLD~~

==Structure of SARM1 bound to SIR3-ADPR==

~~Authors~~: ~~Zhang~~, J., ~~Zheng~~, S., ~~Wang~~, X.

== Structural highlights ==

<table><tr><td colspan='2'>[[9ugj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UGJ OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9UGJ FirstGlance].

~~Description~~: ~~Structure~~ of ~~SARM1 bound~~ to ~~SIR3~~-~~ADPR~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.85Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EO4:[[(2~{S},3~{R},4~{S},5~{S})-5-(4-azanylimidazo[4,5-d]pyridazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[4-methyl-3-(2-oxidanylidene-3~{H}-1,3-benzoxazol-6-yl)pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1EO4</scene></td></tr>

[[Category: ~~Zhang, J~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9ugj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ugj OCA], [https://pdbe.org/9ugj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ugj RCSB], [https://www.ebi.ac.uk/pdbsum/9ugj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ugj ProSAT]</td></tr>

[[Category: ~~Zheng, S~~]]

</table>

[[Category: ~~Wang, X~~]]

== Function ==

[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Wang X]]

[[Category: Zhang J]]

[[Category: Zheng S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9ugj is ON HOLD
+==Structure of SARM1 bound to SIR3-ADPR==
+<StructureSection load='9ugj' size='340' side='right'caption='[[9ugj]], [[Resolution|resolution]] 3.85&Aring;' scene=''>
-Authors: Zhang, J., Zheng, S., Wang, X.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9ugj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UGJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UGJ FirstGlance]. <br>
-Description: Structure of SARM1 bound to SIR3-ADPR
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.85&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EO4:[[(2~{S},3~{R},4~{S},5~{S})-5-(4-azanylimidazo[4,5-d]pyridazin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+[(2~{R},3~{S},4~{R},5~{R})-5-[4-methyl-3-(2-oxidanylidene-3~{H}-1,3-benzoxazol-6-yl)pyridin-1-ium-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methyl+hydrogen+phosphate'>A1EO4</scene></td></tr>
-[[Category: Zhang, J]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ugj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ugj OCA], [https://pdbe.org/9ugj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ugj RCSB], [https://www.ebi.ac.uk/pdbsum/9ugj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ugj ProSAT]</span></td></tr>
-[[Category: Zheng, S]]
+</table>
-[[Category: Wang, X]]
+== Function ==
+[https://www.uniprot.org/uniprot/SARM1_HUMAN SARM1_HUMAN] Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.<ref>PMID:15123841</ref> <ref>PMID:16964262</ref> <ref>PMID:16985498</ref> <ref>PMID:20306472</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Wang X]]
+[[Category: Zhang J]]
+[[Category: Zheng S]]