1vlk: Difference between revisions

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[[Image:1vlk.gif|left|200px]]
{{Seed}}
[[Image:1vlk.png|left|200px]]


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{{STRUCTURE_1vlk|  PDB=1vlk  |  SCENE=  }}  
{{STRUCTURE_1vlk|  PDB=1vlk  |  SCENE=  }}  


'''STRUCTURE OF VIRAL INTERLEUKIN-10'''
===STRUCTURE OF VIRAL INTERLEUKIN-10===




==Overview==
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The crystal structure of Epstein-Barr virus protein BCRF1, an analog of cellular interleukin-10 (IL-10), has been determined at the resolution of 1.9 A and refined to an R-factor 0.191. The structure of this cytokine is similar to that of human IL-10 (hIL-10), forming an intercalated dimer of two 17 kDa polypeptides related by a crystallographic 2-fold symmetry axis. BCRF1 exhibits novel conformations of the N-terminal coil and of the loop between helices A and B compared to hIL-10. These regions are likely to be involved in binding of one or more components of the IL-10 receptor system, and thus the structural differences may account for the lower binding affinity and limited spectrum of biological activities of viral IL-10, compared to hIL-10.
The line below this paragraph, {{ABSTRACT_PUBMED_9159483}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_9159483}}


==About this Structure==
==About this Structure==
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[[Category: Glycoprotein]]
[[Category: Glycoprotein]]
[[Category: Signal]]
[[Category: Signal]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:41:06 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:35:22 2008''
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