1vm1: Difference between revisions

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[[Image:1vm1.~~gif~~|left|200px]]

[[Image:1vm1.png|left|200px]]

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~~'''~~STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM~~'''~~

===STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM===

~~==Overview==~~

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~~Two species resulting from~~ the ~~reaction of~~ the ~~SHV-1 class A beta-lactamase with the sulfone inhibitor tazobactam have been trapped~~ at ~~100 K and mapped by X-ray crystallography at 2~~.~~0 A resolution~~. ~~An acyclic form of tazobactam is covalently bonded to the catalytic Ser70 side chain, and a second species, a five-atom vinyl carboxylic acid fragment of tazobactam~~, is ~~bonded to Ser130. It is proposed that the electron density map of~~ the ~~crystal is a composite picture of two complexes, each with only a single bound species~~. ~~It is estimated that the two complexes exist in the crystal in approximately equal populations. Results are discussed in relation to the mechanism~~-~~based inhibition of class A beta~~-~~lactamases by the similar inhibitors sulbactam and clavulanic acid.~~

The line below this paragraph, {{ABSTRACT_PUBMED_11327849}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 11327849 is the PubMed ID number.

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==About this Structure==

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[[Category: Inhibitor design]]

[[Category: Penicillinase]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:42:11 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:40:08 2008''

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-[[Image:1vm1.gif|left|200px]]
+{{Seed}}
+[[Image:1vm1.png|left|200px]]
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@@ Line 9: / Line 10: @@
 {{STRUCTURE_1vm1|  PDB=1vm1  |  SCENE=  }}
-'''STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM'''
+===STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM===
-==Overview==
+<!--
-Two species resulting from the reaction of the SHV-1 class A beta-lactamase with the sulfone inhibitor tazobactam have been trapped at 100 K and mapped by X-ray crystallography at 2.0 A resolution. An acyclic form of tazobactam is covalently bonded to the catalytic Ser70 side chain, and a second species, a five-atom vinyl carboxylic acid fragment of tazobactam, is bonded to Ser130. It is proposed that the electron density map of the crystal is a composite picture of two complexes, each with only a single bound species. It is estimated that the two complexes exist in the crystal in approximately equal populations. Results are discussed in relation to the mechanism-based inhibition of class A beta-lactamases by the similar inhibitors sulbactam and clavulanic acid.
+The line below this paragraph, {{ABSTRACT_PUBMED_11327849}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 11327849 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_11327849}}
 ==About this Structure==
@@ Line 34: / Line 38: @@
 [[Category: Inhibitor design]]
 [[Category: Penicillinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:42:11 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:40:08 2008''