1vmc: Difference between revisions

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[[Image:1vmc.gif|left|200px]]
{{Seed}}
[[Image:1vmc.png|left|200px]]


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{{STRUCTURE_1vmc|  PDB=1vmc  |  SCENE=  }}  
{{STRUCTURE_1vmc|  PDB=1vmc  |  SCENE=  }}  


'''STROMA CELL-DERIVED FACTOR-1ALPHA (SDF-1ALPHA)'''
===STROMA CELL-DERIVED FACTOR-1ALPHA (SDF-1ALPHA)===




==Overview==
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The solution structure of monomeric stromal cell-derived factor-1alpha (SDF-1alpha), the natural ligand for the CXCR4 G-coupled receptor, has been solved by multidimensional heteronuclear NMR spectroscopy. The structure has a characteristic chemokine fold and is in excellent agreement with the individual subunits observed in the crystal structures of dimeric SDF-1alpha. Using various peptides derived from the N-terminal extracellular tail of the CXCR4 receptor, we show that the principal determinants of binding reside in the N-terminal 17 residues of CXCR4, with a major contribution from the first six residues. From 15N/1HN chemical shift pertubation studies we show that the interaction surface on SDF-1alpha is formed by the undersurface of the three-stranded antiparallel beta-sheet bounded by the N-terminal loop on one side and the C-terminal helix on the other. This surface overlaps with but is not identical to that mapped on several other chemokines for the binding of equivalent peptides derived from their respective receptors.
The line below this paragraph, {{ABSTRACT_PUBMED_15588815}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15588815 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15588815}}


==About this Structure==
==About this Structure==
1VMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMC OCA].  
1VMC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VMC OCA].  


==Reference==
==Reference==
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[[Category: Gozansky, E K.]]
[[Category: Gozansky, E K.]]
[[Category: Cxc-chemokine]]
[[Category: Cxc-chemokine]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:42:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:47:42 2008''

Revision as of 14:47, 27 July 2008

File:1vmc.png

Template:STRUCTURE 1vmc

STROMA CELL-DERIVED FACTOR-1ALPHA (SDF-1ALPHA)

Template:ABSTRACT PUBMED 15588815

About this Structure

1VMC is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Mapping the binding of the N-terminal extracellular tail of the CXCR4 receptor to stromal cell-derived factor-1alpha., Gozansky EK, Louis JM, Caffrey M, Clore GM, J Mol Biol. 2005 Jan 28;345(4):651-8. PMID:15588815

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