User talk:Anders Lewisesquerre: Difference between revisions

Effects of the mammalian neurotrophin family of proteins are accomplished through activation of the tropomyosin-related kinase receptor family (TrkA, TrkB, and TrkC), and the p75 neurotrophin receptor, which is a member of the tumor necrosis factor receptor superfamily. Binding to the p75 neurotrophin receptor leads to neurite outgrowth via Trk modulation, and activation of <scene name='10/1078788/c-jun N-terminal kinase/1'>JNK</scene> (JNK), which leads to apoptosis. As a reference, the complex formed upon binding of Nerve growth factor (NGF) – a neurotrophin with close structural homology to BDNF – to the p75 receptor is <scene name='10/1078788/Ngf_and_p75_receptor/2'>shown</scene>, where NGF is shown in lime, and the p75 receptor is shown in fuchsia. BDNF binds to <scene name='10/1078788/Trkb_receptor/2'>tropomyosin receptor kinase B</scene> (TrkB), which results in activation of three different signaling cascades. These signaling pathways cause activation of CREB and CREB-binding protein (CBP), transcription factors which regulate expression of genes involved in neural plasticity, cell survival, and stress resistance.