User:Elizabeth Cook/Sandbox 1: Difference between revisions
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== Function == | == Function == | ||
The Cat Eye Syndrome Chromosome Region Candidate 2 (CECR2) is the regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes that modulate nucleosome spacing and DNA accessibility during replication and transcription.<ref>PMID:15640247</ref><ref>PMID:22464331</ref><ref>PMID:26365797</ref><ref>PMID:28801535</ref>. CECR2 also plays a key role in the DNA damage repair response, as it inhibits γ-H2AX activity.<ref>PMID:22699752</ref>. CECR2 is involved in various processes during development, including embryogenesis and spermatogenesis.<ref>PMID:22464331,</ref><ref>PMID:26365797</ref>. Recent studies have identified CECR2 as an epigenetic regulator of NF-kB pro-inflammatory gene expression through the recognition of acetylated RelA and driving breast cancer metastasis.<ref>PMID:35108062</ref> | |||
== Domain Organization == | == Domain Organization == | ||
