User:Adam Davis/Sandbox 1: Difference between revisions
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PPARs are ligand-activated transcription factors. The endogenous activators for these receptors are prostaglandins and fatty acids, but synthetic ligands have also been developed for therapeutic use<ref>DOI 10.1016/j.phrs.2004.07.012</ref>. After activation, PPARs form heterodimers with the retinoid X receptor, and the heterodimers bind to DNA, either stimulating or repressing transcription of genes involved in glucose or lipid metabolism. Activation of PPARδ (formerly called PPARβ) improves overall metabolic health. | PPARs are ligand-activated transcription factors. The endogenous activators for these receptors are prostaglandins and fatty acids, but synthetic ligands have also been developed for therapeutic use<ref>DOI 10.1016/j.phrs.2004.07.012</ref>. After activation, PPARs form heterodimers with the retinoid X receptor, and the heterodimers bind to DNA, either stimulating or repressing transcription of genes involved in glucose or lipid metabolism. Activation of PPARδ (formerly called PPARβ) improves overall metabolic health. | ||
PPARδ is found in many tissues, | PPARδ is found in many tissues, but is particularly prominent in muscle. It is important for fatty acid metabolism, and is known to increase insulin sensitivity<ref>DOI 10.1016/j.pharmthera.2009.12.001</ref>. | ||
== Disease == | == Disease == | ||
