User:Elizabeth Cook/Sandbox 1: Difference between revisions
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== Function == | == Function == | ||
The Cat Eye Syndrome Chromosome Region Candidate 2 (CECR2) is the regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes that modulate nucleosome spacing and DNA accessibility during replication and transcription.<ref>PMID:15640247</ref><ref>PMID:22464331</ref><ref>PMID:26365797</ref><ref>PMID:28801535</ref>. CECR2 also plays a key role in the DNA damage repair response, as it inhibits γ-H2AX activity.<ref>PMID:22699752</ref>. CECR2 is involved in various processes during development, including embryogenesis and spermatogenesis.<ref>PMID:22464331 | The Cat Eye Syndrome Chromosome Region Candidate 2 (CECR2) is the regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes that modulate nucleosome spacing and DNA accessibility during replication and transcription.<ref>PMID:15640247</ref><ref>PMID:22464331</ref><ref>PMID:26365797</ref><ref>PMID:28801535</ref>. CECR2 also plays a key role in the DNA damage repair response, as it inhibits γ-H2AX activity.<ref>PMID:22699752</ref>. CECR2 is involved in various processes during development, including embryogenesis and spermatogenesis.<ref>PMID:22464331</ref><ref>PMID:26365797</ref>. Recent studies have identified CECR2 as an epigenetic regulator of NF-kB pro-inflammatory gene expression through the recognition of acetylated RelA and driving breast cancer metastasis.<ref>PMID:35108062</ref> | ||
== Domain Organization == | == Domain Organization == | ||
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[[Image:CECR2 domain org.jpg|400px|]] | [[Image:CECR2 domain org.jpg|400px|]] | ||
CECR2 is composed of | The full-length CECR2 is composed of an N-terminus DDT domain (DNA-binding homeobox and different transcription factors), an AT-hook, and a bromodomain.<ref>DOI: 10.1074/jbc.RA120.014598 </ref><ref>DOI: 10.1387/ijdb.092933jc</ref>The DDT and the AT-hook domain bind DNA, while the bromodomain recognizes acetylated lysine.<ref>DOI: 10.1093/nar/26.19.4413.</ref><ref>DOI: 10.1111/jipb.12069 From NLM Medline.</ref><ref>DOI: 10.1016/j.cell.2012.02.013</ref> | ||
== Sequential and Structural Conservation == | == Sequential and Structural Conservation == | ||
