User:Matthew Chien/Sandbox 1: Difference between revisions
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[[Image:C1q-binding.jpg|thumb|left|260px|C1q binding to antigen-antibody complex]] | [[Image:C1q-binding.jpg|thumb|left|260px|C1q binding to antigen-antibody complex]] | ||
== Introduction == | == Introduction == | ||
'''Complement component 1q''', or <scene name='10/1078778/C1q_globular_head/1'>C1q</scene>, is the first component of the classical pathway of the complement system. C1q is a subcomponent of the Complement component 1 (C1), along with <scene name='10/1078778/C1rc1s/1'>C1r and C1s</scene>. C1q consists of six globular-head regions all connected to a collagen-like region (<scene name='10/1078778/Collagen-like_region_of_c1q/4'>CLR</scene>), with each globular head consisting of 3 separate <scene name='10/1078778/Domains/4'>domains</scene>, having a total mass of roughly 460 kDa. The globular heads entirely consist of β-sheets. The activation of C1q through the binding of the globular head to a variety of epitopes induces structural changes in the collagen-like region of C1q. This activates C1r, which cleaves C1s, which splits into other complement proteins to further activate other aspects of the classical complement system pathway. C1q binds to a variety of different | '''Complement component 1q''', or <scene name='10/1078778/C1q_globular_head/1'>C1q</scene>, is the first component of the classical pathway of the complement system. C1q is a subcomponent of the Complement component 1 (C1), along with <scene name='10/1078778/C1rc1s/1'>C1r and C1s</scene>. C1q consists of six globular-head regions all connected to a collagen-like region (<scene name='10/1078778/Collagen-like_region_of_c1q/4'>CLR</scene>), with each globular head consisting of 3 separate <scene name='10/1078778/Domains/4'>domains</scene>, having a total mass of roughly 460 kDa. The globular heads entirely consist of β-sheets. The activation of C1q through the binding of the globular head to a variety of epitopes induces structural changes in the collagen-like region of C1q. This activates C1r, which cleaves C1s, which splits into other complement proteins to further activate other aspects of the classical complement system pathway. C1q binds to a variety of different epitopes, such as phagocytes to induce phagocytosis, apoptotic cells through phosphatidylserine and DNA to induce apoptosis, and the <scene name='10/1078778/C1q_globular_head_bound_to_igg/2'>Fc</scene> region of IgG and IgM to activate the complement system as described (see [[Antibody]]). C1q acts as a crucial protein that bridges the adaptive and innate immune system. <ref>PMID:29692784</ref><ref>Janeway CA Jr, Travers P, Walport M, et al. Immunobiology: The Immune System in Health and Disease. 5th edition. New York: Garland Science; 2001. The complement system and innate immunity. Available from: https://www.ncbi.nlm.nih.gov/books/NBK27100/</ref><ref>PMID:15388251</ref> | ||
