9k3f: Difference between revisions
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==Cryo-EM structure of the unliganded human melanocortin receptor 3 (MC3R)-Gs complex== | |||
<StructureSection load='9k3f' size='340' side='right'caption='[[9k3f]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9k3f]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9K3F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9K3F FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.75Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9k3f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9k3f OCA], [https://pdbe.org/9k3f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9k3f RCSB], [https://www.ebi.ac.uk/pdbsum/9k3f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9k3f ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MC3R_HUMAN MC3R_HUMAN] Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.[UniProtKB:P33033] | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Bos taurus]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Feng WB]] | |||
[[Category: Wang MW]] | |||
[[Category: Yang DH]] | |||
[[Category: Zheng C]] | |||
[[Category: Zhou QT]] | |||
Latest revision as of 05:44, 6 August 2025
Cryo-EM structure of the unliganded human melanocortin receptor 3 (MC3R)-Gs complex
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