Dual specificity protein kinase 3D structures

3D structures of dual specificity protein kinase

Updated on 29-March-2026

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• CLK1 kinase domain
  • 1z57 – hCLK1 + himenialdizine – human
  • 2vag, 5j1v, 5j1w, 5x8i, 6ft8, 6ft9, 6fyo, 6i5h, 6i5i, 6i5k, 6i5l, 6khd, 6q8k, 6q8p, 6qty, 6r3d, 6r6e, 6r6x, 6r8j, 6raa, 6tw2, 6yta, 6yte, 6ytg, 6yti, 6z4z, 6z50, 6zln, 7ak3, 7o9y, 7oa0, 7opg, 8uwn – hCLK1 + inhibitor
    
  • 6ytd – hCLK1 (mutant) + inhibitor
    
  • 6g33 – hCLK1 + iodotubercidine inhibitor
    
  • 8p08 – hCLK1 + drug
    
• CLK2 kinase domain
  • 3nr9 – hCLK2
    
  • 5unp, 6fyl, 6fyk, 6fyi, 6khe – hCLK2 + inhibitor
    
• CLK3
  • 2eu9 – hCLK3
  • 2exe – hCLK3 kinase domain, phosphorylated
  • 2wu6, 2wu7, 6ft7, 6fyp, 6fyr, 6rct, 6khf, 6ytw, 6yu1, 6z51, 6z52, 6z53, 6z54, 6z55, 9ez3 – hCLK3 kinase domain + inhibitor
  • 6yty, 6z2v – hCLK3 (mutant) + inhibitor
    
  • 3raw - hCLK3 kinase domain + leucettine
• CLK4 kinase domain

 

• • 6fyv – hCLK4 + inhibitor
    
• TTK; Domains: TPR 55-210, kinase 400-808
  • 3cek, 3dbq, 2zmc, 6gvj – hTTK kinase domain
    
  • 4b94, 4h7x, 4h7y - hTTK TPR domain
    
  • 3gfw - hTTK kinase domain + pyrolo-pyridin ligand
  • 3h9f - hTTK kinase domain + pyrimidino-diazepin ligand
  • 2x9e, 3vqu, 3w1f, 3wyx, 3wyy, 3wzj, 3wzk, 4bhz, 4bi0, 4bi1, 4bi2, 4c4e, 4c4f, 4c4g, 4c4h, 4c4i, 4c4j, 4cv8, 4cv9, 4cva, 4d2s, 4js8, 4jt3, 4o6l, 4zeg, 5ap0, 5ap1, 5ap2, 5eh0, 5ehl, 5eho, 5ehy, 5ei2, 5ei6, 5ei8, 5n9s, 5n7v, 5n84, 5n87, 5n93, 5na0, 6b4w, 6h3k, 6n6o, 6tn9, 6tnb, 6tnc, 6tnd, 7chm, 7chn, 7cht, 7cil, 7cja, 7clh, 7lqd - hTTK kinase domain + inhibitor
  • 2zmd, 5ap3, 5ap4, 5ap5, 5ap6, 5ap7, 5o91, 5ntt, 5nad, 5mrb - hTTK kinase domain (mutant) + inhibitor
    
  • 3hmn - hTTK kinase domain + ATP
  • 3hmo - hTTK kinase domain + staurosporine
  • 3hmp - hTTK kinase domain + quinazoline ligand
    
  • 5ljj - hTTK kinase domain + reversine
    

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