1vpt: Difference between revisions

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[[Image:1vpt.jpg|left|200px]]
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[[Image:1vpt.png|left|200px]]


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{{STRUCTURE_1vpt|  PDB=1vpt  |  SCENE=  }}  
{{STRUCTURE_1vpt|  PDB=1vpt  |  SCENE=  }}  


'''AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE'''
===AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE===




==Overview==
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VP39 is a bifunctional vaccinia virus protein that acts as both an mRNA cap-specific RNA 2'-O-methyltransferase and a poly(A) polymerase processivity factor. Here, we report the 1.85 A crystal structure of a VP39 variant complexed with its AdoMet cofactor. VP39 comprises a single core domain with structural similarity to the catalytic domains of other methyltransferases. Surface features and mutagenesis data suggest two possible RNA-binding sites with novel underlying architecture, one of which forms a cleft spanning the region adjacent to the methyltransferase active site. This report provides a prototypic structure for an RNA methyltransferase, a protein that interacts with the mRNA 5' cap, and an intact poxvirus protein.
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{{ABSTRACT_PUBMED_8612277}}


==About this Structure==
==About this Structure==
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[[Category: Rna cap]]
[[Category: Rna cap]]
[[Category: Vaccinia]]
[[Category: Vaccinia]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:46:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:46:11 2008''

Revision as of 17:46, 27 July 2008

File:1vpt.png

Template:STRUCTURE 1vpt

AS11 VARIANT OF VACCINIA VIRUS PROTEIN VP39 IN COMPLEX WITH S-ADENOSYL-L-METHIONINE

Template:ABSTRACT PUBMED 8612277

About this Structure

1VPT is a Single protein structure of sequence from Vaccinia virus. Full crystallographic information is available from OCA.

Reference

The 1.85 A structure of vaccinia protein VP39: a bifunctional enzyme that participates in the modification of both mRNA ends., Hodel AE, Gershon PD, Shi X, Quiocho FA, Cell. 1996 Apr 19;85(2):247-56. PMID:8612277

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