1vpw: Difference between revisions

Line 1:

[[Image:1vpw.~~gif~~|left|200px]]

[[Image:1vpw.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA~~'''~~

===STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA===

~~==Overview==~~

<!--

The ~~crystal structure of the purine repressor mutant L54M bound to hypoxanthine and to the purF operator provides a stereochemical understanding of the high DNA affinity of~~ this ~~hinge helix mutant. Comparison of~~ the ~~PurR L54M-DNA complex~~ to ~~that of~~ the wild type PurR-DNA complex reveals that these purine repressors bind and kink DNA similarly despite significant differences in their minor groove contacts and routes to interdigitation of the central C.G:G.~~C base pair step~~. ~~Modeling studies, supported by genetic and biochemical data~~, ~~show that the stereochemistry of the backbone atoms of the abutting hinge helices combined with the rigidity of~~ the ~~kinked base pair step constrain the interdigitating residue to leucine or methionine for the LacI/GalR family of transcription regulators~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9628480}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9628480 is the PubMed ID number.

-->

==About this Structure==

Line 28:

Line 32:

[[Category: Dna-binding regulatory protein]]

[[Category: Minor groove bending]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:46:40 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:10:45 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1vpw.gif|left|200px]]
+{{Seed}}
+[[Image:1vpw.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1vpw|  PDB=1vpw  |  SCENE=  }}
-'''STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA'''
+===STRUCTURE OF THE PURR MUTANT, L54M, BOUND TO HYPOXANTHINE AND PURF OPERATOR DNA===
-==Overview==
+<!--
-The crystal structure of the purine repressor mutant L54M bound to hypoxanthine and to the purF operator provides a stereochemical understanding of the high DNA affinity of this hinge helix mutant. Comparison of the PurR L54M-DNA complex to that of the wild type PurR-DNA complex reveals that these purine repressors bind and kink DNA similarly despite significant differences in their minor groove contacts and routes to interdigitation of the central C.G:G.C base pair step. Modeling studies, supported by genetic and biochemical data, show that the stereochemistry of the backbone atoms of the abutting hinge helices combined with the rigidity of the kinked base pair step constrain the interdigitating residue to leucine or methionine for the LacI/GalR family of transcription regulators.
+The line below this paragraph, {{ABSTRACT_PUBMED_9628480}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9628480 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9628480}}
 ==About this Structure==
@@ Line 28: / Line 32: @@
 [[Category: Dna-binding regulatory protein]]
 [[Category: Minor groove bending]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:46:40 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:10:45 2008''