User talk:Anders Lewisesquerre: Difference between revisions
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Brain-derived neurotrophic factor (BDNF) is a 13kDa signaling protein belonging to the neurotrophin family of growth factors. This family of growth factors are critical in the development, differentiation, and survival of neurons. Mammalian members of the neurotrophin family of growth factors include Nerve growth factor (NGF) | Brain-derived neurotrophic factor (BDNF) is a 13kDa signaling protein belonging to the neurotrophin family of growth factors. This family of growth factors are critical in the development, differentiation, and survival of neurons. Mammalian members of the neurotrophin family of growth factors include Nerve growth factor (NGF) | ||
[https://www.rcsb.org/structure/6XUO PDB structure], neurotrophin-3 (NT-3) [https://www.rcsb.org/structure/1B8K PDB structure], and neurotrophin-4/5 (NT-4/5) [https://www.rcsb.org/structure/1B98 PDB structure of neurotrophin-4/5]. | [https://www.rcsb.org/structure/6XUO PDB structure], neurotrophin-3 (NT-3) [https://www.rcsb.org/structure/1B8K PDB structure], and neurotrophin-4/5 (NT-4/5) [https://www.rcsb.org/structure/1B98 PDB structure of neurotrophin-4/5]. | ||
[[Image:BDNF_TGN_1.jpg]]BDNF is synthesized in the Endoplasmic reticulum as a 32-35 kDa precursor (pro BDNF). This precursor is processed in the golgi-apparaturs and its terminal domain is cleaved by a convertase, the mature BDNF protein is then passed through the trans-golgi network and secreted by secretory vesicles out of the plasma membrane. BDNF is primarily expressed in the brain, where it is found in the hippocampus, cortex, amygdala, and striatum, and less so in the hypothalamus. BDNF is also expressed in peripheral tissues, such as the kidneys, retina, prostate, motor neurons, skeletal muscle. | [[Image:BDNF_TGN_1.jpg]] | ||
BDNF is synthesized in the Endoplasmic reticulum as a 32-35 kDa precursor (pro BDNF). This precursor is processed in the golgi-apparaturs and its terminal domain is cleaved by a convertase, the mature BDNF protein is then passed through the trans-golgi network and secreted by secretory vesicles out of the plasma membrane. BDNF is primarily expressed in the brain, where it is found in the hippocampus, cortex, amygdala, and striatum, and less so in the hypothalamus. BDNF is also expressed in peripheral tissues, such as the kidneys, retina, prostate, motor neurons, skeletal muscle. | |||
