9nyy: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
The entry | ==Nucleic acid bound human SLFN14, State 1== | ||
<StructureSection load='9nyy' size='340' side='right'caption='[[9nyy]], [[Resolution|resolution]] 2.73Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9nyy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9NYY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9NYY FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.73Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9nyy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9nyy OCA], [https://pdbe.org/9nyy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9nyy RCSB], [https://www.ebi.ac.uk/pdbsum/9nyy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9nyy ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Autosomal dominant thrombocytopenia with platelet secretion defect. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SLN14_HUMAN SLN14_HUMAN] Shows no ribosome-associated and endoribonuclease activities.<ref>PMID:25996083</ref> Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner (By similarity). Involved in correct maturation of megakaryocytes and especially important for proplatelet extension.[UniProtKB:G1SRW8]<ref>PMID:25996083</ref> <ref>PMID:26769223</ref> <ref>PMID:25996083</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Maheshwari S]] | |||
[[Category: Martinez-Claros AO]] | |||
[[Category: Pillon MC]] | |||
[[Category: Schneiderman H]] | |||
[[Category: Van Riper J]] | |||
[[Category: Wang L]] | |||
Latest revision as of 16:27, 9 July 2025
Nucleic acid bound human SLFN14, State 1
| ||||||||||||
