9r2e: Difference between revisions

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'''Unreleased structure'''


The entry 9r2e is ON HOLD
==Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1==
 
<StructureSection load='9r2e' size='340' side='right'caption='[[9r2e]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
Authors: Pannecoucke, E., Voet, S., Deweirdt, L., Verbeiren, J., Gabriels, S., Provost, M., Freier, R., Koenig, J., Lammens, A., Silence, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9r2e]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R2E FirstGlance]. <br>
Description: Structure of ARGX-121 Fab fragment in complex with the Fc fragment of IgA1
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
[[Category: Verbeiren, J]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r2e OCA], [https://pdbe.org/9r2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r2e RCSB], [https://www.ebi.ac.uk/pdbsum/9r2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r2e ProSAT]</span></td></tr>
[[Category: Voet, S]]
</table>
[[Category: Silence, K]]
== Disease ==
[[Category: Gabriels, S]]
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Note=A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein.
[[Category: Provost, M]]
== Function ==
[[Category: Pannecoucke, E]]
[https://www.uniprot.org/uniprot/IGHA1_HUMAN IGHA1_HUMAN] Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system.
[[Category: Koenig, J]]
__TOC__
[[Category: Lammens, A]]
</StructureSection>
[[Category: Freier, R]]
[[Category: Homo sapiens]]
[[Category: Deweirdt, L]]
[[Category: Large Structures]]
[[Category: Deweirdt L]]
[[Category: Freier R]]
[[Category: Gabriels S]]
[[Category: Koenig J]]
[[Category: Lammens A]]
[[Category: Pannecoucke E]]
[[Category: Provost M]]
[[Category: Silence K]]
[[Category: Verbeiren J]]
[[Category: Voet S]]
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