9o1q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9o1q is ~~ON HOLD until Paper Publication~~

==TMEM16F D409G mutant in liposomes in the presence of Ca2+ (active state)==

~~Authors~~: ~~Feng~~, Z., ~~Accardi~~, A.

== Structural highlights ==

<table><tr><td colspan='2'>[[9o1q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O1Q OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=9O1Q FirstGlance].

~~Description~~: ~~TMEM16F D409G mutant~~ in ~~liposomes~~ in the ~~presence~~ of ~~Ca2+ (active state)~~

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

[[Category: Accardi, A]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=9o1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o1q OCA], [https://pdbe.org/9o1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o1q RCSB], [https://www.ebi.ac.uk/pdbsum/9o1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o1q ProSAT]</td></tr>

[[Category: Feng, Z]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/ANO6_MOUSE ANO6_MOUSE] Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.<ref>PMID:21107324</ref> <ref>PMID:21908539</ref> <ref>PMID:22936354</ref> <ref>PMID:23021219</ref> <ref>PMID:23532839</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Mus musculus]]

[[Category: Accardi A]]

[[Category: Feng Z]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9o1q is ON HOLD  until Paper Publication
+==TMEM16F D409G mutant in liposomes in the presence of Ca2+ (active state)==
+<StructureSection load='9o1q' size='340' side='right'caption='[[9o1q]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
-Authors: Feng, Z., Accardi, A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9o1q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9O1Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9O1Q FirstGlance]. <br>
-Description: TMEM16F D409G mutant in liposomes in the presence of Ca2+ (active state)
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
-[[Category: Accardi, A]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9o1q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9o1q OCA], [https://pdbe.org/9o1q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9o1q RCSB], [https://www.ebi.ac.uk/pdbsum/9o1q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9o1q ProSAT]</span></td></tr>
-[[Category: Feng, Z]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ANO6_MOUSE ANO6_MOUSE] Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.<ref>PMID:21107324</ref> <ref>PMID:21908539</ref> <ref>PMID:22936354</ref> <ref>PMID:23021219</ref> <ref>PMID:23532839</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Accardi A]]
+[[Category: Feng Z]]