9qsm: Difference between revisions

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'''Unreleased structure'''


The entry 9qsm is ON HOLD  until Paper Publication
==small molecule inhibitor in complex with PD-L1==
 
<StructureSection load='9qsm' size='340' side='right'caption='[[9qsm]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
Authors: Muszak, D., Kocik-Krol, J., Zaber, J., Kruc, O., Palej, U., Fijolkowska, K., Maslanka, A., Magiera-Mularz, K., Plewka, J., Stec, M., Siedlar, M., Musielak, B., Kitel, R., Skalniak, L., Surmiak, E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9qsm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QSM FirstGlance]. <br>
Description: small molecule inhibitor in complex with PD-L1
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1JAE:~{N}-[2-chloranyl-3-[2-chloranyl-3-[4-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]-3-methoxy-phenyl]phenyl]phenyl]-5-[[[2-(hydroxymethyl)-1,3-bis(oxidanyl)propan-2-yl]amino]methyl]pyridine-2-carboxamide'>A1JAE</scene></td></tr>
[[Category: Surmiak, E]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qsm OCA], [https://pdbe.org/9qsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qsm RCSB], [https://www.ebi.ac.uk/pdbsum/9qsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qsm ProSAT]</span></td></tr>
[[Category: Kocik-Krol, J]]
</table>
[[Category: Musielak, B]]
== Function ==
[[Category: Palej, U]]
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref>
[[Category: Maslanka, A]]
== References ==
[[Category: Kitel, R]]
<references/>
[[Category: Siedlar, M]]
__TOC__
[[Category: Magiera-Mularz, K]]
</StructureSection>
[[Category: Skalniak, L]]
[[Category: Homo sapiens]]
[[Category: Fijolkowska, K]]
[[Category: Large Structures]]
[[Category: Zaber, J]]
[[Category: Fijolkowska K]]
[[Category: Plewka, J]]
[[Category: Kitel R]]
[[Category: Kruc, O]]
[[Category: Kocik-Krol J]]
[[Category: Stec, M]]
[[Category: Kruc O]]
[[Category: Muszak, D]]
[[Category: Magiera-Mularz K]]
[[Category: Maslanka A]]
[[Category: Musielak B]]
[[Category: Muszak D]]
[[Category: Palej U]]
[[Category: Plewka J]]
[[Category: Siedlar M]]
[[Category: Skalniak L]]
[[Category: Stec M]]
[[Category: Surmiak E]]
[[Category: Zaber J]]
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