1vs7: Difference between revisions

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[[Image:1vs7.~~gif~~|left|200px]]

[[Image:1vs7.png|left|200px]]

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~~'''~~Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.~~'''~~

===Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.===

~~==Overview==~~

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The ~~prokaryotic ribosome is an important target of antibiotic action. We determined~~ the ~~X-ray structure of~~ the ~~aminoglycoside kasugamycin~~ (~~Ksg) in complex with the Escherichia coli 70S ribosome~~ at 3.~~5-A resolution~~. ~~The structure reveals that the drug binds within the messenger RNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA~~, ~~which are sites of Ksg resistance. To our surprise, Ksg resistance mutations do not inhibit binding of~~ the ~~drug to the ribosome~~. ~~The present structural and biochemical results indicate that inhibition by Ksg and Ksg resistance are closely linked to the structure of the mRNA at the junction of the peptidyl~~-~~tRNA and exit~~-~~tRNA sites (P and E sites).~~

The line below this paragraph, {{ABSTRACT_PUBMED_16998486}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16998486 is the PubMed ID number.

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==About this Structure==

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[[Category: Kasugamycin]]

[[Category: Ribosome]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 12~~:51:42 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:23:42 2008''

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-[[Image:1vs7.gif|left|200px]]
+{{Seed}}
+[[Image:1vs7.png|left|200px]]
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 {{STRUCTURE_1vs7|  PDB=1vs7  |  SCENE=  }}
-'''Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.'''
+===Crystal structure of the bacterial ribosome from escherichia coli in complex with the antibiotic kasugamyin at 3.5a resolution. this file contains the 30s subunit of one 70s ribosome. the entire crystal structure contains two 70s ribosomes and is described in remark 400.===
-==Overview==
+<!--
-The prokaryotic ribosome is an important target of antibiotic action. We determined the X-ray structure of the aminoglycoside kasugamycin (Ksg) in complex with the Escherichia coli 70S ribosome at 3.5-A resolution. The structure reveals that the drug binds within the messenger RNA channel of the 30S subunit between the universally conserved G926 and A794 nucleotides in 16S ribosomal RNA, which are sites of Ksg resistance. To our surprise, Ksg resistance mutations do not inhibit binding of the drug to the ribosome. The present structural and biochemical results indicate that inhibition by Ksg and Ksg resistance are closely linked to the structure of the mRNA at the junction of the peptidyl-tRNA and exit-tRNA sites (P and E sites).
+The line below this paragraph, {{ABSTRACT_PUBMED_16998486}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16998486 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16998486}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Kasugamycin]]
 [[Category: Ribosome]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:51:42 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:23:42 2008''