9lre: Difference between revisions
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==Cryo-EM structure of the histamine H4 receptor-Gi protein complex (Overall)== | |||
<StructureSection load='9lre' size='340' side='right'caption='[[9lre]], [[Resolution|resolution]] 2.84Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9lre]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9LRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9LRE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HSM:HISTAMINE'>HSM</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9lre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9lre OCA], [https://pdbe.org/9lre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9lre RCSB], [https://www.ebi.ac.uk/pdbsum/9lre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9lre ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: Nureki | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Akasaka H]] | |||
[[Category: Itoh Y]] | |||
[[Category: Kise Y]] | |||
[[Category: Kobayashi K]] | |||
[[Category: Kusakizako T]] | |||
[[Category: Matsuzaki Y]] | |||
[[Category: Nureki O]] | |||
[[Category: Oshima HS]] | |||
[[Category: Sano FK]] | |||
[[Category: Shihoya W]] | |||
[[Category: Tanaka T]] | |||
Latest revision as of 06:37, 23 July 2025
Cryo-EM structure of the histamine H4 receptor-Gi protein complex (Overall)
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