9ocg: Difference between revisions
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==Transporter associated with antigen processing (TAP) bound to the viral protein BNLF2a in the inward-facing state== | |||
<StructureSection load='9ocg' size='340' side='right'caption='[[9ocg]], [[Resolution|resolution]] 3.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ocg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OCG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OCG FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ocg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ocg OCA], [https://pdbe.org/9ocg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ocg RCSB], [https://www.ebi.ac.uk/pdbsum/9ocg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ocg ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/TAP2_HUMAN TAP2_HUMAN] Immunodeficiency by defective expression of HLA class 1. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TAP2_HUMAN TAP2_HUMAN] Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Human gammaherpesvirus 4]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen J]] | |||
[[Category: Lee J]] | |||
[[Category: Manon V]] | |||
Latest revision as of 04:16, 14 September 2025
Transporter associated with antigen processing (TAP) bound to the viral protein BNLF2a in the inward-facing state
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