1z92: Difference between revisions
New page: left|200px<br /> <applet load="1z92" size="450" color="white" frame="true" align="right" spinBox="true" caption="1z92, resolution 2.8Å" /> '''structure of interle... |
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[[Image:1z92.gif|left|200px]]<br /> | [[Image:1z92.gif|left|200px]]<br /><applet load="1z92" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1z92, resolution 2.8Å" /> | caption="1z92, resolution 2.8Å" /> | ||
'''structure of interleukin-2 with its alpha receptor'''<br /> | '''structure of interleukin-2 with its alpha receptor'''<br /> | ||
==Overview== | ==Overview== | ||
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds | Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules. | ||
==Disease== | ==Disease== | ||
Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]] | Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147730 147730]], Severe combined immunodeficiency due to IL2 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147680 147680]] | ||
==About this Structure== | ==About this Structure== | ||
1Z92 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1Z92 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z92 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Boulanger, M | [[Category: Boulanger, M J.]] | ||
[[Category: Garcia, K | [[Category: Garcia, K C.]] | ||
[[Category: Goriatcheva, N.]] | [[Category: Goriatcheva, N.]] | ||
[[Category: Rickert, M.]] | [[Category: Rickert, M.]] | ||
[[Category: Wang, X | [[Category: Wang, X Q.]] | ||
[[Category: interleukin-2]] | [[Category: interleukin-2]] | ||
[[Category: interleukin-2 alpha receptor]] | [[Category: interleukin-2 alpha receptor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:13:14 2008'' | ||
Revision as of 14:13, 21 February 2008
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structure of interleukin-2 with its alpha receptor
Overview
Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.
Disease
Known diseases associated with this structure: Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[147730], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680]
About this Structure
1Z92 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:15933202
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