9r6v: Difference between revisions
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==Crystal structure of the DOC domain of the E3 ligase HECTD3== | |||
<StructureSection load='9r6v' size='340' side='right'caption='[[9r6v]], [[Resolution|resolution]] 1.61Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9r6v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9R6V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9R6V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.61Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9r6v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9r6v OCA], [https://pdbe.org/9r6v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9r6v RCSB], [https://www.ebi.ac.uk/pdbsum/9r6v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9r6v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HECD3_HUMAN HECD3_HUMAN] E3 ubiquitin ligases accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of TRIOBP and its subsequent proteasomal degradation, thus facilitating cell cycle progression by regulating the turn-over of TRIOBP. Mediates also ubiquitination of STX8 (By similarity).[UniProtKB:Q3U487]<ref>PMID:18194665</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Esposito D]] | |||
[[Category: Huber J]] | |||
[[Category: Maslen S]] | |||
[[Category: Rittinger K]] | |||
Latest revision as of 14:40, 10 February 2026
Crystal structure of the DOC domain of the E3 ligase HECTD3
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