1zaf: Difference between revisions
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New page: left|200px<br /> <applet load="1zaf" size="450" color="white" frame="true" align="right" spinBox="true" caption="1zaf, resolution 2.20Å" /> '''Crystal structure o... |
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[[Image:1zaf.gif|left|200px]]<br /> | [[Image:1zaf.gif|left|200px]]<br /><applet load="1zaf" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1zaf" size=" | |||
caption="1zaf, resolution 2.20Å" /> | caption="1zaf, resolution 2.20Å" /> | ||
'''Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one'''<br /> | '''Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one'''<br /> | ||
==Overview== | ==Overview== | ||
The syntheses of a series of 2-arylindene-1-ones as potent ligands of | The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity. | ||
==About this Structure== | ==About this Structure== | ||
1ZAF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 789 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http:// | 1ZAF is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=789:'>789</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZAF OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Harris, H | [[Category: Harris, H A.]] | ||
[[Category: Malamas, M | [[Category: Malamas, M S.]] | ||
[[Category: Manas, E | [[Category: Manas, E S.]] | ||
[[Category: McDevitt, R | [[Category: McDevitt, R E.]] | ||
[[Category: Miller, C | [[Category: Miller, C P.]] | ||
[[Category: Unwalla, R | [[Category: Unwalla, R J.]] | ||
[[Category: Xu, Z | [[Category: Xu, Z B.]] | ||
[[Category: 789]] | [[Category: 789]] | ||
[[Category: agonist]] | [[Category: agonist]] | ||
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[[Category: transcription factor]] | [[Category: transcription factor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 16:13:39 2008'' | ||
Revision as of 14:13, 21 February 2008
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Crystal structure of estrogen receptor beta complexed with 3-Bromo-6-hydroxy-2-(4-hydroxy-phenyl)-inden-1-one
Overview
The syntheses of a series of 2-arylindene-1-ones as potent ligands of ERbeta and ERalpha are described. Several compounds exhibited high potency and moderate selectivity for the ERbeta receptor. X-ray and modeling studies were used to understand ligand binding orientation and observed affinity.
About this Structure
1ZAF is a Protein complex structure of sequences from Homo sapiens with 789 as ligand. Active as Histone acetyltransferase, with EC number 2.3.1.48 Full crystallographic information is available from OCA.
Reference
Estrogen receptor ligands: design and synthesis of new 2-arylindene-1-ones., McDevitt RE, Malamas MS, Manas ES, Unwalla RJ, Xu ZB, Miller CP, Harris HA, Bioorg Med Chem Lett. 2005 Jun 15;15(12):3137-42. PMID:15876535
Page seeded by OCA on Thu Feb 21 16:13:39 2008
