1w07: Difference between revisions

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[[Image:1w07.gif|left|200px]]
{{Seed}}
[[Image:1w07.png|left|200px]]


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{{STRUCTURE_1w07|  PDB=1w07  |  SCENE=  }}  
{{STRUCTURE_1w07|  PDB=1w07  |  SCENE=  }}  


'''ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1'''
===ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1===




==Overview==
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The peroxisomal acyl-CoA oxidase family plays an essential role in lipid metabolism by catalyzing the conversion of acyl-CoA into trans-2-enoyl-CoA during fatty acid beta-oxidation. Here, we report the X-ray structure of the FAD-containing Arabidopsis thaliana acyl-CoA oxidase 1 (ACX1), the first three-dimensional structure of a plant acyl-CoA oxidase. Like other acyl-CoA oxidases, the enzyme is a dimer and it has a fold resembling that of mammalian acyl-CoA oxidase. A comparative analysis including mammalian acyl-CoA oxidase and the related tetrameric mitochondrial acyl-CoA dehydrogenases reveals a substrate-binding architecture that explains the observed preference for long-chained, mono-unsaturated substrates in ACX1. Two anions are found at the ACX1 dimer interface and for the first time the presence of a disulfide bridge in a peroxisomal protein has been observed. The functional differences between the peroxisomal acyl-CoA oxidases and the mitochondrial acyl-CoA dehydrogenases are attributed to structural differences in the FAD environments.
The line below this paragraph, {{ABSTRACT_PUBMED_15581893}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15581893 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15581893}}


==About this Structure==
==About this Structure==
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[[Category: Oxidoreductase]]
[[Category: Oxidoreductase]]
[[Category: Peroxisomal beta-oxidation]]
[[Category: Peroxisomal beta-oxidation]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 12:58:51 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:10:46 2008''

Revision as of 18:10, 28 July 2008

File:1w07.png

Template:STRUCTURE 1w07

ARABIDOPSIS THALIANA ACYL-COA OXIDASE 1

Template:ABSTRACT PUBMED 15581893

About this Structure

1W07 is a Single protein structure of sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA.

Reference

Acyl-CoA oxidase 1 from Arabidopsis thaliana. Structure of a key enzyme in plant lipid metabolism., Pedersen L, Henriksen A, J Mol Biol. 2005 Jan 21;345(3):487-500. PMID:15581893

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