9ole: Difference between revisions
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==Crystal Structure of PI5P4KIIAlpha complex with 066ATZ== | |||
<StructureSection load='9ole' size='340' side='right'caption='[[9ole]], [[Resolution|resolution]] 2.40Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9ole]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9OLE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9OLE FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.404Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1CCL:(7~{R})-8-cyclopentyl-5-methyl-7-(pyridin-2-ylmethyl)-2-[[5-(1~{H}-1,2,3,4-tetrazol-5-yl)-1,3-thiazol-2-yl]amino]-7~{H}-pteridin-6-one'>A1CCL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ole FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ole OCA], [https://pdbe.org/9ole PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ole RCSB], [https://www.ebi.ac.uk/pdbsum/9ole PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ole ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN] Precursor B-cell acute lymphoblastic leukemia. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.<ref>PMID:18364242</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ha Y]] | |||
[[Category: He Z]] | |||
Latest revision as of 06:28, 22 April 2026
Crystal Structure of PI5P4KIIAlpha complex with 066ATZ
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