9qyj: Difference between revisions

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'''Unreleased structure'''


The entry 9qyj is ON HOLD  until Paper Publication
==Crystal structure of human S-adenosyl-L-homocysteine hydrolase in complex with adenosine and cadmium ions.==
 
<StructureSection load='9qyj' size='340' side='right'caption='[[9qyj]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
Authors: Malecki, P.H., Imiolczyk, B., Gawel, M., Stepniewska, M., Brzezinski, K.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9qyj]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9QYJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9QYJ FirstGlance]. <br>
Description: Crystal structure of human S-adenosyl-L-homocysteine hydrolase in complex with adenosine and cadmium ions.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
[[Category: Imiolczyk, B]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9qyj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9qyj OCA], [https://pdbe.org/9qyj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9qyj RCSB], [https://www.ebi.ac.uk/pdbsum/9qyj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9qyj ProSAT]</span></td></tr>
[[Category: Malecki, P.H]]
</table>
[[Category: Brzezinski, K]]
== Disease ==
[[Category: Gawel, M]]
[https://www.uniprot.org/uniprot/SAHH_HUMAN SAHH_HUMAN] Defects in AHCY are the cause of hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) [MIM:[https://omim.org/entry/613752 613752]. A metabolic disorder characterized by hypermethioninemia associated with failure to thrive, mental and motor retardation, facial dysmorphism with abnormal hair and teeth, and myocardiopathy.<ref>PMID:15024124</ref> <ref>PMID:16736098</ref> <ref>PMID:19177456</ref> <ref>PMID:20852937</ref>
[[Category: Stepniewska, M]]
== Function ==
[https://www.uniprot.org/uniprot/SAHH_HUMAN SAHH_HUMAN] Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.<ref>PMID:12590576</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brzezinski K]]
[[Category: Gawel M]]
[[Category: Imiolczyk B]]
[[Category: Malecki PH]]
[[Category: Stepniewska M]]
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