1w30: Difference between revisions

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[[Image:1w30.gif|left|200px]]
{{Seed}}
[[Image:1w30.png|left|200px]]


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{{STRUCTURE_1w30|  PDB=1w30  |  SCENE=  }}  
{{STRUCTURE_1w30|  PDB=1w30  |  SCENE=  }}  


'''PYRR OF MYCOBACTERIUM TUBERCULOSIS AS A POTENTIAL DRUG TARGET'''
===PYRR OF MYCOBACTERIUM TUBERCULOSIS AS A POTENTIAL DRUG TARGET===




==Overview==
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The Mycobacterium tuberculosis pyrR gene (Rv1379) encodes a protein that regulates the expression of pyrimidine-nucleotide biosynthesis (pyr) genes in a UMP-dependent manner. Because pyrimidine biosynthesis is an essential step in the progression of TB, the gene product pyrR is an attractive antitubercular drug target. The 1.9 A native structure of Mtb pyrR determined by the TB Structural Genomics Consortium facilities in trigonal space group P3(1)21 is reported, with unit-cell parameters a = 66.64, c = 154.72 A at 120 K and two molecules in the asymmetric unit. The three-dimensional structure and residual uracil phosphoribosyltransferase activity point to a common PRTase ancestor for pyrR. However, while PRPP- and UMP-binding sites have been retained in Mtb pyrR, a distinct dimer interaction among subunits creates a deep positively charged cleft capable of binding pyr mRNA. In silico screening of pyrimidine-nucleoside analogs has revealed a number of potential lead compounds that, if bound to Mtb pyrR, could facilitate transcriptional attenuation, particularly cyclopentenyl nucleosides.
The line below this paragraph, {{ABSTRACT_PUBMED_15805589}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 15805589 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15805589}}


==About this Structure==
==About this Structure==
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[[Category: Pyrr,transferase,glycosyltransferase,psi,protein structure initiative,tb structural genomics consortium,tb]]
[[Category: Pyrr,transferase,glycosyltransferase,psi,protein structure initiative,tb structural genomics consortium,tb]]
[[Category: Tbsgc]]
[[Category: Tbsgc]]
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