1w31: Difference between revisions

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[[Image:1w31.gif|left|200px]]
{{Seed}}
[[Image:1w31.png|left|200px]]


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{{STRUCTURE_1w31|  PDB=1w31  |  SCENE=  }}  
{{STRUCTURE_1w31|  PDB=1w31  |  SCENE=  }}  


'''YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX'''
===YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX===




==Overview==
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The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA).
The line below this paragraph, {{ABSTRACT_PUBMED_16131755}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16131755}}


==About this Structure==
==About this Structure==
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[[Category: Tim barrel]]
[[Category: Tim barrel]]
[[Category: Zinc]]
[[Category: Zinc]]
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