1w33: Difference between revisions

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[[Image:1w33.gif|left|200px]]
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{{STRUCTURE_1w33|  PDB=1w33  |  SCENE=  }}  
{{STRUCTURE_1w33|  PDB=1w33  |  SCENE=  }}  


'''BBCRASP-1 FROM BORRELIA BURGDORFERI'''
===BBCRASP-1 FROM BORRELIA BURGDORFERI===




==Overview==
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Borrelia burgdorferi, a spirochete transmitted to human hosts during feeding of infected Ixodes ticks, is the causative agent of Lyme disease. Serum-resistant B. burgdorferi strains cause a chronic, multisystemic form of the disease and bind complement factor H (FH) and FH-like protein 1 (FHL-1) on the spirochete surface. Here we report the atomic structure for the key FHL-1- and FH-binding protein BbCRASP-1 and reveal a homodimer that presents a novel target for drug design.
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{{ABSTRACT_PUBMED_15711564}}


==About this Structure==
==About this Structure==
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[[Category: Membrane protein]]
[[Category: Membrane protein]]
[[Category: Tick]]
[[Category: Tick]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:05:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:04:55 2008''

Revision as of 01:05, 28 July 2008

File:1w33.png


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1w33, resolution 2.70Å (default scene)
Ligands: GOL
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



BBCRASP-1 FROM BORRELIA BURGDORFERI

Template:ABSTRACT PUBMED 15711564

About this Structure

1W33 is a Single protein structure of sequence from Borrelia burgdorferi. Full crystallographic information is available from OCA.

Reference

A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi., Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM, Nat Struct Mol Biol. 2005 Mar;12(3):276-7. Epub 2005 Feb 13. PMID:15711564

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