9on2: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "9on2" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
==Cryo-EM structure of a tetrameric XRCC3-RAD51C-RAD51D-XRCC2 complex== | |||
<StructureSection load='9on2' size='340' side='right'caption='[[9on2]], [[Resolution|resolution]] 3.16Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9on2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9ON2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9ON2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.16Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9on2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9on2 OCA], [https://pdbe.org/9on2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9on2 RCSB], [https://www.ebi.ac.uk/pdbsum/9on2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9on2 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/XRCC3_HUMAN XRCC3_HUMAN] Disease susceptibility is associated with variants affecting the gene represented in this entry. Disease susceptibility may be associated with variants affecting the gene represented in this entry. Variant p.Thr341Met has been reported to be associated with an increased risk for CMM6 (PubMed:11059748). Further studies have shown that this variant is functional in homology-directed DNA repair, and the association of XRCC3 with CMM6 has not been confirmed (PubMed:12037675, PubMed:12376526, PubMed:26137085, PubMed:26922354).<ref>PMID:11059748</ref> <ref>PMID:12037675</ref> <ref>PMID:12376526</ref> <ref>PMID:26137085</ref> <ref>PMID:26922354</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/XRCC3_HUMAN XRCC3_HUMAN] Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex CX3 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, CX3 acts downstream of RAD51 recruitment; the complex binds predominantly to the intersection of the four duplex arms of the Holliday junction (HJ) and to junctions of replication forks. Involved in HJ resolution and thus in processing HR intermediates late in the DNA repair process; the function may be linked to the CX3 complex and seems to involve GEN1 during mitotic cell cycle progression. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51 and RAD51C.<ref>PMID:14716019</ref> <ref>PMID:20413593</ref> <ref>PMID:23108668</ref> <ref>PMID:23149936</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Jia L]] | |||
[[Category: Kwon Y]] | |||
[[Category: Olsen SK]] | |||
[[Category: Rawal Y]] | |||
[[Category: Ruben EA]] | |||
[[Category: Sung P]] | |||
[[Category: Wasmuth EV]] | |||
Latest revision as of 15:53, 1 April 2026
Cryo-EM structure of a tetrameric XRCC3-RAD51C-RAD51D-XRCC2 complex
| ||||||||||||
