9rbd: Difference between revisions

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'''Unreleased structure'''


The entry 9rbd is ON HOLD  until Paper Publication
==Cryo-EM structure of ANP amyloids from left atrial appendage of atrial fibrillation patient - polymorph A==
 
<StructureSection load='9rbd' size='340' side='right'caption='[[9rbd]], [[Resolution|resolution]] 2.96&Aring;' scene=''>
Authors: Broggini, L., Chaves-Sanjuan, A., Ricagno, S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9rbd]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9RBD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9RBD FirstGlance]. <br>
Description: Cryo-EM structure of ANP amyloids from left atrial appendage of atrial fibrillation patient -polymorph A
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.96&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9rbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9rbd OCA], [https://pdbe.org/9rbd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9rbd RCSB], [https://www.ebi.ac.uk/pdbsum/9rbd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9rbd ProSAT]</span></td></tr>
[[Category: Broggini, L]]
</table>
[[Category: Chaves-Sanjuan, A]]
== Disease ==
[[Category: Ricagno, S]]
[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN] Defects in NPPA are the cause of familial atrial fibrillation type 6 (ATFB6) [MIM:[https://omim.org/entry/612201 612201]. Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity, progressive deterioration of atrial electromechanical function and ineffective pumping of blood into the ventricles. It can be associated with palpitations, syncope, thromboembolic stroke, and congestive heart failure.<ref>PMID:18614783</ref>
== Function ==
[https://www.uniprot.org/uniprot/ANF_HUMAN ANF_HUMAN] Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.<ref>PMID:1672777</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Broggini L]]
[[Category: Chaves-Sanjuan A]]
[[Category: Ricagno S]]
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