1w45: Difference between revisions

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[[Image:1w45.gif|left|200px]]
{{Seed}}
[[Image:1w45.png|left|200px]]


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{{STRUCTURE_1w45|  PDB=1w45  |  SCENE=  }}  
{{STRUCTURE_1w45|  PDB=1w45  |  SCENE=  }}  


'''THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.'''
===THE 2.5 ANGSTROEM STRUCTURE OF THE K16A MUTANT OF ANNEXIN A8, WHICH HAS AN INTACT N-TERMINUS.===




==Overview==
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Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus. The structure is closest to that of annexin A3 and highlights several important regions of inherent flexibility in the annexin molecule. The N terminus resembles that of annexin A3, as it lies along the concave surface of the molecule and inserts partially into the hydrophilic channel in its centre. Since both annexins A3 and A8 are expressed in promyelocytic cells during their differentiation, the similarity in their structures might suggest a functional relationship.
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{{ABSTRACT_PUBMED_15644210}}


==About this Structure==
==About this Structure==
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[[Category: Cxalcium and membrane-binding protein]]
[[Category: Cxalcium and membrane-binding protein]]
[[Category: Intact n-terminus]]
[[Category: Intact n-terminus]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 13:07:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:41:51 2008''
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