9ub2: Difference between revisions

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'''Unreleased structure'''


The entry 9ub2 is ON HOLD  until Paper Publication
==Crystal structure of human DHODH in complex with inhibitor 006==
 
<StructureSection load='9ub2' size='340' side='right'caption='[[9ub2]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Jun, L., Zhaomin, X., Caiyue, C., Yuanyuan, Z., Jin, H.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9ub2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9UB2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9UB2 FirstGlance]. <br>
Description: Crystal structure of human DHODH in complex with inhibitor 006
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1EOU:(4~{R})-2-[(3-cyclobutyloxy-4-phenyl-pyridin-2-yl)amino]-4,5,6,7-tetrahydro-1,3-benzothiazol-4-ol'>A1EOU</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Caiyue, C]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9ub2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9ub2 OCA], [https://pdbe.org/9ub2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9ub2 RCSB], [https://www.ebi.ac.uk/pdbsum/9ub2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9ub2 ProSAT]</span></td></tr>
[[Category: Jin, H]]
</table>
[[Category: Zhaomin, X]]
== Disease ==
[[Category: Yuanyuan, Z]]
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[https://omim.org/entry/263750 263750]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
[[Category: Jun, L]]
== Function ==
[https://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Caiyue C]]
[[Category: Jin H]]
[[Category: Jun L]]
[[Category: Yuanyuan Z]]
[[Category: Zhaomin X]]
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